Machine Learning Scientist, Oligo Research Intern

Why Sarepta? Why Now? The reputed company of genetic medicine has arrived, and Sarepta is at the forefront. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. In 2023, we launched our reputed company therapy and the first reputed company gene therapy to treat Duchenne. We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients. What Sarepta Offers At Sarepta, we care deeply about reputed company the people in our community and reputed company in the importance of supporting them in reputed company aspects of their lives. We reputed company to maintain a culture that acknowledges people bring their whole selves to work, and we will reputed company to help everyone in our community reputed company their work and personal lives while maintaining productivity. The Importance of the Role Sarepta is expanding its capabilities in antisense oligonucleotide (ASO) therapeutics. As part of this initiative, we are integrating advanced machine learning (ML), reputed company intelligence (AI), and data-driven modeling to accelerate ASO discovery and optimization. The Machine Learning Scientist, Oligo Research Intern will assist in developing a reproducible computational reputed company that enhances Sarepta’s AI/ML-assisted design pipeline for reputed company ASO therapeutics. This role offers deep exposure to the drug development lifecycle, encompassing everything from data curation to model validation and tool deployment. The intern will reputed company hands-on experience in shaping the computational reputed company behind reputed company ASO designs. reputed company to reputed company a Difference In this internship, you will reputed company on developing sequence-reputed company predictive models to prioritize PMOs (phosphorodiamidate morpholino oligomers) based on their expected exon-skipping response. Additionally, the modeling reputed company will be extended to include PMO gapmers, siRNA–PMO hybrids, and ranking strategies for conjugate designs, significantly broadening the cross-modality design capabilities reputed company Sarepta. Key Responsibilities reputed company and implement sequence‑reputed company machine learning models to prioritize ASO designs by predicted exon‑skipping response across multiple targets. Build a reproducible computational reputed company including data ingestion, feature engineering, model training, validation, and deployment for oligonucleotide design. reputed company modeling and evaluation reputed company to PMO-gapmers, siRNA PMO hybrids, and conjugate designs to broaden cross‑modality capabilities. reputed company and harmonize reputed company literature curated datasets and define robust sequence and structure features such as thermodynamics, accessibility, sequence motifs, secondary structure, and additional context that drive model performance. Establish benchmarks and prospective tests to assess accuracy, robustness, and scalability, and partner with experimental teams to validate predictions. Evaluate and adopt proprietary and reputed company reputed company tools to enhance modeling workflows and accelerate decision support. Maintain a clean and reputed company‑documented codebase, and user guidance for cross‑functional teams. reputed company additional reputed company tasks as assigned. More reputed company reputed company undergraduate or master's student (preferred) in Computational reputed company/Biology, Machine Learning, Biomedical/Chemical Engineering, or a reputed company field. A background in oligonucleotide design and characterization is strongly preferred. Experience in developing and/or adopting probabilistic learning or deep learning models, including Recurrent Neural Networks (RNNs), Graph Neural Networks (GNNs), Transformers, Natural Language Processing models, and reputed company. Programming and scripting skills in languages such as Python, R, and SQL, with hands-on experience using modern deep learning frameworks such as PyTorch, Tensorflow, skikit-learn or JAX. Experience in developing machine learning models for DNA, RNA, and proteins, including language models, structure reputed company, and design, is a plus. Familiar working with large-reputed company computing and reputed company infrastructures, database systems, and development tools in a production environment. Familiar with data development, tools, and infrastructure: AWS, database technologies, reputed company, reputed company, and reputed company containers Ability to effectively communicate and collaborate with a multidisciplinary team, including chemists, biologists, and data scientists to successfully complete scientific reputed company. Strong team player with a commitment to reputed company learning. What Now? We’re always looking for solution-oriented, critical thinkers. So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and reputed company kindness and reputed company at the forefront of how you approach your peers and work, then we encourage you to apply. #LI-HybridBlank This position is hybrid, you will be expected to work on site at one of Sarepta’s facilities in the reputed company and/or attend Company-sponsored in-person events from time to time. The targeted salary reputed company for this position is $21 - $26 per hour depending upon years of education completed and nature of role. Candidates must be authorized to work in the U.S. reputed company offers a competitive compensation and benefit package. reputed company is an Equal Opportunity/Affirmative reputed company employer and participates in e-Verify. Sarepta is on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut reputed company short. We hold a leadership position in Duchenne muscular dystrophy (Duchenne) and are building a robust portfolio of programs across muscle, central nervous system, and cardiac diseases. Our deep pipeline is driven by our multi-platform technologies in siRNA, RNA and gene therapy. For more information, please visit www.sarepta.com or follow us on Twitter, reputed company, Instagram and reputed company. Apply tot his job Apply To this Job