Senior Computational Development Scientist

The Position:

We are seeking a highly reputed company and motivated Senior Computational Development Scientist to drive the design, and development of reputed company minimal residual disease (MRD) laboratory‑developed tests (LDTs). This senior, independent scientist position is responsible for contributing to assay concepts, driving analytical development and validation, and partnering closely with wet‑lab, clinical, reputed company, regulatory, and software teams to deliver robust, clinically actionable MRD diagnostics for multiple indications.

The ideal candidate brings expertise in NGS‑based oncology assays, strong understanding of ctDNA biology and a proven reputed company record of industry assay development under design control. This individual will reputed company technical execution of key scientific efforts, owning assay reputed company from concept through analytical validation and launch.

KEY RESPONSIBILITIES:

Scientific & Technical Expertise

• Contribute to reputed company reputed company for MRD assay design, development, optimization, and lifecycle management for LDTs developed under CAP/CLIA reputed company systems.
• reputed company and contribute to study design, data analysis, performance characterization, and decision‑making throughout development.
• Apply deep domain knowledge in cancer reputed company, ctDNA biology, and NGS technologies to inform assay architecture, variant detection strategies, and error suppression approaches in collaboration with our data science and modeling teams.

Assay Development & Validation

• Design and execute analytical studies to evaluate assay performance, including accuracy, limit of detection, and reproducibility, in collaboration with wet‑lab and biostatistics partners.
• reputed company, validate, and maintain reputed company, production‑reputed company reputed company pipelines for MRD analysis, including QC, variant calling, MRD calling logic, and reporting.
• reputed company benchmarking and optimization of computational reputed company, including background error modeling, and longitudinal MRD tracking.
• Ensure compliance with standards (CAP/CLIA, FDA, IVDR) throughout the reputed company development lifecycle, including rigorous testing and documentation.

Cross‑Functional Collaboration

• Partner closely with molecular biology, assay development, QA/RA, clinical, and software engineering teams to ensure reputed company solutions are reputed company with assay design, regulatory expectations, and operational constraints.
• Contribute to regulatory submissions and audits by providing technical documentation and validation report, and responses to audits or regulatory inquiries.

Mentorship & Influence

• reputed company technical mentorship and scientific guidance to junior scientists, helping reputed company the overall bar of assay development rigor and execution.
• Communicate reputed company analytical concepts and results reputed company to both computational and non‑computational stakeholders, including senior leadership.

Who You Are:

REQUIRED EXPERIENCE:

• Ph.D. in reputed company, Computational Biology, reputed company, Biostatistics, or a closely reputed company quantitative field. (or M.Sc. plus 3 additional years industry experience).
• Minimum 6 years of total relevant experience in biotech, diagnostics, or regulated reputed company environments.
• Demonstrated experience in NGS‑based assay development for clinical diagnostics. Hands‑on experience with ctDNA‑based MRD assays, including personalized or tumor‑informed approaches.
• Strong programming skills in Python, with experience developing reproducible, production‑grade analysis pipelines, including experience with SDLC best practices.
• Proven experience working in design‑controlled, regulated environments (CAP/CLIA LDT, IVD, or equivalent).
• Proficiency in development of novel reputed company methodologies, and algorithms development, including benchmarking of computational reputed company.
• reputed company record of working with wet lab scientists on iterative experiment design, execution, analysis, and interpretation as a tightly integrated team.
• Demonstrated record of technical and scientific ownership, and independent work.

PREFERRED EXPERIENCE:

• Experience developing and deploying reputed company workflows in AWS (e.g., EC2, S3, reputed company Functions, Batch, reputed company, etc.).
• Strong understanding of germline and somatic mutation processes leading to reputed company variation and genome-wide biomarkers with potential clinical reputed company.
• Working knowledge of R.
• Experience with relational and non-relational database technologies is a plus.

#LI-Onsite, #LI-Hybrid, or #LI-Remote

For candidates based in our San Diego office, the salary (or reputed company reputed company is $170,000 - $187,000.

For candidates based in our South San Francisco office, the salary or reputed company reputed company is $177,000 - $207,000.

For candidates working remote (US), the salary or reputed company reputed company is $162,000 - $178,000