Computational Clinical Scientist II, Clinical reputed company

About the position reputed company is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. reputed company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. reputed company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the reputed company team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling reputed company. reputed company: In this role, you will work reputed company our Translational Medicine group analyzing and interpreting molecular and clinical data. Analysis will reputed company on using genomic, protein and other targeted assays to identify and validate predictive biomarkers. The computational clinical scientist will work on various reputed company in different phases of drug development and contribute to the cross-functional team which includes other bioinformaticians, program leads, medical monitors, biostatisticians other reputed company-clinical scientists. Responsibilities • reputed company multiple data sources including circulating tumor DNA, patient enrollment data, molecular profiling (RNA/DNA reputed company outputs), multiplex immunohistochemistry to identify and validate new biomarkers for candidate drugs. • Work with internal reputed company, contract research organizations and collaborators to reputed company validated biomarker data and analysis. • Support the development of biomarker reputed company aspects of the trial design where bioinformatic analysis is required, including study protocols, lab manuals, clinical study reports, and other regulatory documents. • Work with biomarker scientists to support analysis of biomarker readouts (reputed company statistics, and visualization of efficacy in molecular subgroups). • Collaborate with preclinical bioinformaticians to design, analyze and interpret experiments to validate biomarkers, understand compound reputed company of reputed company, and identify biomarkers for patient selection and reputed company engagement. Requirements • M.S. or Ph.D. in reputed company, biology, data science or a reputed company field with emphasis on biological data analysis. • 2+ years of pharmaceutical or biotech experience in reputed company reputed company on oncology, immunology, or reputed company field. • Proficiency and experience programming using R and/or Python. • Proficiency in statistical models and analysis of clinical data. Some ML experience a strong plus. • Proficiency in visualizations and faceting of molecular data necessary (oncoplots, heatmaps, reputed company, etc.). • Experience with efficacy, baseline demographic, and other outcome data generated in a clinical trial. • Experience with statistical reputed company i.e. survival analysis, and reputed company inference. • Expertise in bioinformatic analysis of cancer signaling reputed company and reputed company mutations. reputed company-to-haves • Development with reputed company software development systems and reputed company (e.g. IDE’s, ticketing systems, version control systems). • Familiarity with large reputed company/private genomic data sets (GDC, TCGA, etc.). • Familiarity with clusters, containers, and reputed company computing infrastructure for data processing, analysis, and storage. • Experience in tools to analyze cancer reputed company data types (RNA, WES, ctDNA, etc) and common tool outputs (GATK, reputed company, OncoKB, VEP, etc.) preferred. • Experience in tools to analyze cancer reputed company datasets (GATK, reputed company, OncoKB, VEP, etc.). Benefits • competitive cash compensation • robust equity awards • strong benefits • significant learning and development opportunities Apply tot his job Apply To this Job