Associate Scientist- Biological Sciences in King of Prussia, PA

Job title: Associate Scientist- Biological Sciences in King of Prussia, PA at GlaxoSmithKline
Company: GlaxoSmithKline
Job description: The Senior Scientist leads the manufacture of clinical supply of investigational biopharmaceutical molecules. Specifically, hands-on cGMP mid to large scale purification of bulk drug substance for use in early phase clinical trials.The key responsibilities of the role include the following:

• Performs hands-on processing of large-scale purification steps under cGMP regulatory conditions. Processing steps include: Column packing, Chromatography, UltraFiltration/DiaFiltration, Depth Filtration, Bulk Drug Fill
• Executes and overseas production of clinical supplies based on established scientific procedures and protocols and implements improvements with minimal supervision; interprets data and draws conclusions from the data
• Completes activities requiring independent thought that have the potential to comprise 50-100% of the employee’s time depending on production campaigns
• Supports the technology transfer process through active participation in ensuring that new processes fit and execute consistently
• Performs cleaning/sanitization of equipment and associated parts utilizing equipment washers, Clean-In-Place (CIP) systems as well as manual cleaning methods
• Prepares, assembles and sterilizes via autoclave of equipment and process components
• Prepares buffers, including weigh and dispense, formulation, and filtration activities
• In addition to manufacturing responsibilities, works on projects and assignments where independent action and a high degree of initiative are required in order to resolve problems and make recommendations

This role will provide YOU the opportunity to lead key activities to progress YOUR career. The responsibilities of the role include the following:

• Leads or works on projects and assignments where independent action and a high degree of initiative and knowledge are required for execution or to provide recommendations
• Anticipates/recognizes potential problems with equipment and/or supplies, and proactively seeks input from other Scientists to take action to solve or prevent problems
• Represent the group during cross-functional initiatives
• Serve as Subject Matter Expert (SME)
• Train and mentor less experienced manufacturing scientists
• Recognizes potential safety and compliance problems and takes action to rectify
• Troubleshoots problems in the execution of processing activities; proactively assesses options and impact and takes action to rectify or communicate to appropriate decision makers
• Authors Standard Operating Procedures (SOPs), Safety Assessments, and various other protocols with minimal supervision
• Reviews and approves executed documentation, Buffer Forms, and/or Batch Records prior to submission to Quality Assurance (QA) to insure adherence to cGMPs and proper documentation practices
• Leads deviation investigations and implementation of CAPAs stemming from Safety or Compliance observations
• Identifies process improvement opportunities with impact on safety, compliance, and efficiency/cost

Why you?Basic Qualifications:We are looking for professionals with these required skills to achieve our goals:

• Bachelor’s degree Chemical Engineering, Biology, Chemistry, or other engineering or scientific field OR 2-4 years of equivalent experience.
• Must be available to work off-shift hours: early mornings, late evenings/nights, and weekends if necessary

Preferred Qualifications:

• Experience in a Good Manufacturing Practices (GMP) environment
• Large-scale downstream manufacturing experience
• Thorough knowledge of routine laboratory/plant equipment and demonstrates high level of technical expertise with working familiarity with a number of methods, techniques, laboratory procedures and processes
• Demonstrates good interpersonal skills, and communicates well both verbally and through written communications. Maintains a professional and productive relationship with area management and co-workers
• Ability to work as self-starter and handle multiple priorities in a dynamic cross-functional team based environment

Please visit to learn more about the comprehensive benefits program GSK offers US employees.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at
Expected salary:
Location: King of Prussia, PA
Job date: Wed, 30 Apr 2025 04:01:09 GMT
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