Senior Scientist I, Protein Biochemistry/Enzymology

About the position Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. We are looking for a highly motivated and driven biochemist/enzymologist to join the Discovery Biology team at Revolution Medicines. The ideal candidate will have a deep knowledge of enzyme kinetics, excitement about investigating detailed biochemical mechanisms, and the ability to apply this knowledge to practical, data-driven decisions. The scientist in this position will: Design, develop, and apply biochemical assays to functionally characterize proteins, understand their role in oncology, and enable hit finding and validation efforts. Perform kinetic studies to support a deep understanding of small molecules with complex mechanisms of action, including covalent and non-covalent molecular glue inhibitors and activators. Contribute to early discovery efforts to validate novel oncology targets and therapeutic modalities. Support cross-functional teams to generate novel insights and drive drug discovery and development. Effectively communicate findings to diverse audiences through presentations, reports, and publications. Responsibilities • Design, develop, and apply biochemical assays to functionally characterize proteins, understand their role in oncology, and enable hit finding and validation efforts. • Perform kinetic studies to support a deep understanding of small molecules with complex mechanisms of action, including covalent and non-covalent molecular glue inhibitors and activators. • Contribute to early discovery efforts to validate novel oncology targets and therapeutic modalities. • Support cross-functional teams to generate novel insights and drive drug discovery and development. • Effectively communicate findings to diverse audiences through presentations, reports, and publications. Requirements • Ph.D. in Biochemistry, Enzymology, Chemical Biology, or a related field with 5-8 years of experience, preferably in an industrial setting. • Thorough understanding of enzyme kinetics and the ability to design, analyze, and interpret experimental results. • Hands-on experience handling recombinant proteins and analyzing activity through experimental assays (fluorescence, absorbance, luminescence, FRET, mass spectrometry, etc.). • Rigorous and detail-oriented approach to data analysis and interpretation. • Knowledge of protein structure-function interpretation and proficiency with software to visualize protein structures. • Strong analytical and problem-solving skills with the ability to work independently. • Excellent written and verbal communication skills, including the ability to communicate complex concepts to a variety of audiences. Nice-to-haves • Experience in target ID and hit ID stage programs in biotech. • Proficient with software to model multi-step enzyme reactions (DynaFit, SimBiology, PySB, etc.). • Familiarity with modern laboratory automation, data systems, and analytics and ability to design experiments to take advantage of these systems. Apply tot his job Apply To this Job