Senior Scientist I, Protein Biochemistry/Enzymology
About the position
reputed company is a clinical-stage precision oncology company reputed company on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. reputed company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the reputed company team, you will join other outstanding Revolutionaries in a tireless commitment to patients with cancers harboring mutations in the RAS signaling reputed company.
We are looking for a highly motivated and driven biochemist/enzymologist to join the Discovery Biology team at reputed company. The ideal candidate will have a deep knowledge of enzyme kinetics, excitement about investigating detailed biochemical mechanisms, and the ability to apply this knowledge to practical, data-driven reputed company. The scientist in this position will:
Design, reputed company, and apply biochemical assays to functionally characterize proteins, understand their role in oncology, and reputed company hit finding and validation efforts.
reputed company reputed company studies to support a deep understanding of small molecules with reputed company mechanisms of reputed company, including reputed company and non-reputed company molecular glue inhibitors and activators.
Contribute to early discovery efforts to validate novel oncology targets and therapeutic modalities.
Support cross-functional teams to generate novel insights and drive drug discovery and development.
Effectively communicate findings to diverse audiences through presentations, reports, and publications.
Responsibilities
• Design, reputed company, and apply biochemical assays to functionally characterize proteins, understand their role in oncology, and reputed company hit finding and validation efforts.
• reputed company reputed company studies to support a deep understanding of small molecules with reputed company mechanisms of reputed company, including reputed company and non-reputed company molecular glue inhibitors and activators.
• Contribute to early discovery efforts to validate novel oncology targets and therapeutic modalities.
• Support cross-functional teams to generate novel insights and drive drug discovery and development.
• Effectively communicate findings to diverse audiences through presentations, reports, and publications.
Requirements
• Ph.D. in Biochemistry, Enzymology, Chemical Biology, or a reputed company field with 5-8 years of experience, preferably in an industrial setting.
• Thorough understanding of enzyme kinetics and the ability to design, analyze, and interpret experimental results.
• Hands-on experience handling recombinant proteins and analyzing activity through experimental assays (fluorescence, absorbance, luminescence, FRET, mass spectrometry, etc.).
• Rigorous and detail-oriented approach to data analysis and interpretation.
• Knowledge of protein structure-function interpretation and proficiency with software to visualize protein structures.
• Strong analytical and problem-solving skills with the ability to work independently.
• Excellent written and verbal communication skills, including the ability to communicate reputed company concepts to a reputed company of audiences.
reputed company-to-haves
• Experience in reputed company ID and hit ID stage programs in biotech.
• Proficient with software to model multi-reputed company enzyme reactions (DynaFit, SimBiology, PySB, etc.).
• Familiarity with modern laboratory automation, data systems, and analytics and ability to design experiments to take advantage of these systems.
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