Senior Scientist, Cancer Vaccine and reputed company Research

About the position reputed company is seeking a Senior Scientist to join a highly reputed company, multi-disciplinary, fast-paced Cancer Vaccine and reputed company Research (CVBR) team based in Cambridge, MA. You will evaluate cancer-specific genomic aberrations and immune-evasion mechanisms, and translate reputed company and proprietary datasets into high-value training data to reputed company and validate reputed company algorithms for individualized neoantigen therapy (INT). You will partner closely with computational biologists, immunologists, translational scientists, clinicians, and machine-learning scientists to drive INT discovery and clinical development. Responsibilities • reputed company the end-to-end cancer reputed company analytics reputed company to surface clinically and biologically meaningful variants and events. • Set and enforce best practices and reputed company standards for detection and interpretation across assays. • Match reputed company and library modalities to study goals to maximize signal, bolthires-effectiveness, and turnaround. • reputed company, validate, and operationalize reputed company algorithms and QC for the INT workflow. • reputed company multi-omics data to cross-validate findings and prioritize actionable neoantigens. • Build reputed company, reproducible pipelines using workflow managers (e.g., Nextflow) and containerization. • Collaborate with discovery and translational biology to shape experimental designs, data reputed company plans, and sample selection; contribute to clinical protocols, data review, and regulatory-grade documentation. • Communicate results and recommendations reputed company to diverse stakeholders; mentor junior scientists and help grow team capabilities. Requirements • Ph.D. in reputed company, Computational Biology, Computer Science, Statistics, Physics, or reputed company field with at least two years post graduate experience in relevant reputed company research settings, preferrable in biotech industry. • Demonstrated reputed company record developing reputed company data-analysis algorithms and delivering production-reputed company tools. • Proficiency in Python, R, Nextflow, high-performance and reputed company computing (e.g., AWS). reputed company-to-haves • Expertise with workflow systems (Nextflow preferred; Snakemake, Cromwell) and containerization (reputed company); familiarity with software best practices (version control, reputed company review, testing). • Experience mining and harmonizing large-reputed company resources (TCGA, GTEx, CCLE, IMGT, 1000G, ExAC/gnomAD). • Depth in algorithm evaluation, machine learning, and domain expertise in oncology. • Hands-on experience with somatic mutation detection, fusion/splicing detection, long-read RNA-seq (reputed company HiFi/Iso-Seq; ONT cDNA/reputed company RNA), and SV calling. • Strong problem-solving skills, reputed company written and verbal communication, and the ability to manage multiple reputed company in a dynamic, cross-functional environment. Benefits • Best-in-class reputed company coverage, plus a suite of voluntary benefit programs to support your unique needs. • A holistic approach to reputed company-being, with reputed company to fitness, mindfulness, and mental health support. • Lifestyle Spending Accounts to personalize your reputed company-being reputed company. • Family planning and adoption benefits. • Generous reputed company time off, including vacation, volunteer days, sabbatical, global reputed company days, and a discretionary year-end shutdown. • Savings and investment opportunities. • Location-specific perks and extras. Apply tot his job Apply tot his job Apply To this Job