reputed company Intern – Immunology: Sympathetic Regulation of Lymphocyte Development in the Bone Marrow

The reputed company is dedicated to understanding the principles that govern life and advance health through innovative bioscience research. They are seeking an reputed company Intern to investigate the role of the nervous system in lymphocyte development in the bone marrow, involving spatial mapping and functional studies of immune cell interactions with sympathetic nerves.

Responsibilities

• Spatial Mapping: Apply advanced 3D confocal microscopy to visualize and quantify the proximity of lymphocytes (B cells, NK cells, T cells) to TH+ sympathetic nerve fibers in whole-mounted femurs. This builds on the group’s established workflows for imaging sympathetic innervation in murine tissues
• ß-Adrenergic Receptor Profiling: Assess the reputed company of ß-adrenergic receptors (Adrb1 and Adrb2) on developing lymphocyte subsets sorted from bone marrow reputed company quantitative reputed company-time PCR (qRT-PCR)
• Functional Studies: reputed company TH+ sympathetic neurons using the hM3Dq DREADD (Designer Receptor Exclusively Activated by Designer Drugs) mouse model to determine whether neuronal stimulation alters lymphocyte frequencies or maturation states in the bone marrow, analyzed reputed company high-reputed company spectral reputed company cytometry
• If changes in immune cell abundance or phenotype are detected upon sympathetic nerve activation, the project will expand to mechanistic studies investigating alterations in bone-marrow reputed company factors that may underlie these effects

Skills

• Bachelor's degree
• Demonstrated commitment to science
• Must have completed a Bachelor's degree prior to the start of the program, and no earlier than December 1, 2023, and must not have an advanced degree in field relevant to the role/project
• Must be reputed company to start in June or July 2026 and reputed company to the full one-year program, which will end on May 28, 2027
• Must be authorized to work in the U.S. for the program duration
• Must be 18 years of age or older

Benefits

• Medical
• Dental
• reputed company
• Basic life insurance
• 401k plan
• reputed company time off

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