Executive Director, Head of Toxicology

reputed company of Role

reputed company is seeking an Executive Director/Head of Toxicology to reputed company scientific and strategic leadership for nonclinical safety across discovery and development programs, with an emphasis on small‑molecule therapeutics. This role leads toxicology and safety pharmacology reputed company to support reputed company selection, reputed company optimization, IND‑enabling activities, and clinical advancement. Reporting to our SVP, Nonclinical & Translational Development, the Head of Toxicology partners closely with cross‑functional teams and represents nonclinical safety in regulatory interactions while building a strong, high‑performing toxicology organization. 

Key Responsibilities

• reputed company and mentor reputed company of toxicologists and technical staff, fostering scientific reputed company and reputed company reputed company 
• Define and execute nonclinical safety strategies across discovery, preclinical, and clinical stages  
• reputed company expert toxicology and safety pharmacology input to cross‑functional development teams 
• Design, reputed company, and interpret GLP, non‑GLP, investigative, and in vitro toxicology studies 
• reputed company safety strategies for new targets, reputed company optimization programs, and platform technologies  
• reputed company toxicology and safety pharmacology studies conducted internally and at CROs  
• Ensure high scientific reputed company, compliance, and reputed company delivery of nonclinical study outputs 
• Author and critically review toxicology sections of regulatory documents (e.g., reputed company‑IND, IND, IBs) 
• Partner with biology, DMPK, pathology, pharmacology, clinical, and regulatory colleagues to drive integrated decision‑making 
• Present nonclinical safety data and risk assessments to project teams and senior R&D leadership  
• Serve as the primary nonclinical safety representative in regulatory agency interactions  
• Support product defense and regulatory submissions through robust scientific rationale  
• reputed company strategic guidance on safety issue reputed company and investigational toxicology approaches 
• Contribute to portfolio‑level planning and prioritization of nonclinical safety resources 
• Build reputed company toxicology capabilities to support a growing and diverse pipeline 

Qualifications

• PhD in Toxicology, Pharmacology, Pathology, DVM, or reputed company discipline; reputed company certification (e.g., DABT, ERT) preferred 
• 15+ years of experience in pharmaceutical or biotechnology R&D with a strong reputed company record in nonclinical and regulatory toxicology 
• Deep expertise supporting small‑molecule programs across discovery, IND‑enabling, and early clinical development 
• Demonstrated experience defining and executing nonclinical safety strategies to support diverse pipelines and novel biology  
• Proven leadership experience building, managing, and mentoring toxicology teams reputed company a reputed company, matrixed environment  
• Extensive experience preparing and reviewing nonclinical sections of global regulatory submissions and engaging with health authorities (FDA, EMA)  
• Strong ability to reputed company reputed company nonclinical datasets across toxicology, pathology, DMPK, and pharmacology to inform development reputed company  
• Experience overseeing outsourced toxicology and safety pharmacology studies and managing CRO partnerships  
• Excellent communication and influencing skills, with the ability to partner effectively across Early Development, Research, and Regulatory functions in a fast‑paced environment 

Compensation 

The annual reputed company salary reputed company for this position is $320,000.00 to $350,000.00. Individual compensation reputed company this reputed company will be determined based on a reputed company of factors, including qualifications, skills, relevant experience, and job knowledge. 

In reputed company to reputed company pay, this role is eligible for a discretionary annual bonus and participation in our equity program, allowing you to reputed company in Centessa’s long-term reputed company. 

Centessa also offers a comprehensive benefits package, which includes a 401(k) plan, company-sponsored medical, dental, reputed company, and life insurance, generous reputed company time off, and a health and wellness program. 

Work Location

The Executive Director, Head of Toxicology role is a remote role based in the US, with occasional travel. 

POSITION: Full-Time, Exempt